to screw sth up or to screw up sth
+ holiday, plan, job搞砸
The car broke down, so that screwed up our holiday.汽车抛锚了, 把我们的假日也给毁了。
They screwed things up big time.他们把事情彻底搞砸了。
+ machine使失去作用
Opening the window screws up the air conditioning.打开窗户空调就失去作用了。